Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC018
Sex MALE
Dominant hand LEFT
Test date and time 2022-03-31 13:23
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl madopar 250mg 2x 1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 41 individuals with a value less than 0.74 were subsequently diagnosed with PD. That is, 97.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.74 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 9, 'TN': 8, 'TP': 33, 'FP': 22}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 25, 'TN': 20, 'TP': 17, 'FP': 10}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 5
timePerCircleMean 13.872
timePerCircleCoV 0.23995
timePerCircleSlope -0.0475779
meanError 2.20463
tremorFreq 5.07812
tremorRelPower 29.3394
tremorGyroAmpMean 0.0160975
tremorGyroAmpSlope -0.00129199
tremorGyroAmpCoV 0.434316
tremorCoordAmpMean 0.0438296
tremorCoordAmpSlope 0.00125644
tremorCoordAmpCoV 0.398149
tremorAccAmpMean 0.0412487
tremorAccAmpSlope -0.0015666
tremorAccAmpCoV 0.419951
tremorPcRelVar 0.578132
tremorPcX 0.92008
tremorPcY 0.391731

Circle Segment 1

Duration 19.12 s, Accuracy Estimate 3.706 (lower is better)

Circle Segment 2

Duration 9.96 s, Accuracy Estimate 1.737 (lower is better)

Circle Segment 3

Duration 12.8 s, Accuracy Estimate 1.988 (lower is better)

Circle Segment 4

Duration 13.36 s, Accuracy Estimate 1.635 (lower is better)

Circle Segment 5

Duration 14.12 s, Accuracy Estimate 1.958 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 39.176
timePerSpiralCoV 0.161022
timePerSpiralSlope 0.028787
meanError 1.73924
tremorFreq 6.54297
tremorRelPower 27.4893
tremorGyroAmpMean 0.0144886
tremorGyroAmpSlope 0.00022116
tremorGyroAmpCoV 0.44788
tremorCoordAmpMean 0.0437859
tremorCoordAmpSlope -0.00156739
tremorCoordAmpCoV 0.768265
tremorAccAmpMean 0.0263045
tremorAccAmpSlope 0.000214618
tremorAccAmpCoV 0.419807
tremorPcRelVar 0.537561
tremorPcX 0.657218
tremorPcY 0.753701

Spiral Segment 1

Duration 40.64 s, Accuracy Estimate 1.686 (lower is better)

Spiral Segment 2

Duration 35.64 s, Accuracy Estimate 1.636 (lower is better)

Spiral Segment 3

Duration 26.08 s, Accuracy Estimate 1.73 (lower is better)

Spiral Segment 4

Duration 35.6 s, Accuracy Estimate 1.825 (lower is better)

Spiral Segment 5

Duration 46.76 s, Accuracy Estimate 1.764 (lower is better)

Spiral Segment 6

Duration 36.92 s, Accuracy Estimate 1.719 (lower is better)

Spiral Segment 7

Duration 40.2 s, Accuracy Estimate 1.798 (lower is better)

Spiral Segment 8

Duration 39.36 s, Accuracy Estimate 1.682 (lower is better)

Spiral Segment 9

Duration 42.04 s, Accuracy Estimate 1.657 (lower is better)

Spiral Segment 10

Duration 48.52 s, Accuracy Estimate 1.897 (lower is better)

Elel

eDurationMean 0.402069
eDurationStd 0.084419
eDurationStdnorm 0.209962
eDurationMedian 0.385017
eDurationQuartdelta 0.0600026
eDurationQuartdeltanorm 0.155844
eDurationKurt 6.54366
eDurationTrenddiff -0.0300013
eDurationTrendratio 0.925
eWidthMean 6.36974
eWidthStd 1.34783
eWidthStdnorm 0.211598
eWidthMedian 6.24406
eWidthQuartdelta 1.71766
eWidthQuartdeltanorm 0.275088
eWidthKurt 3.09336
eWidthTrenddiff 0.819
eWidthTrendratio 1.13725
eHeightMean 15.2399
eHeightStd 2.57111
eHeightStdnorm 0.168709
eHeightMedian 15.444
eHeightQuartdelta 3.55463
eHeightQuartdeltanorm 0.230163
eHeightKurt 2.33544
eHeightTrenddiff -2.106
eHeightTrendratio 0.869565
eAspectMean 0.425375
eAspectStd 0.0974892
eAspectStdnorm 0.229184
eAspectMedian 0.428369
eAspectQuartdelta 0.148876
eAspectQuartdeltanorm 0.347542
eAspectKurt 2.75155
eAspectTrenddiff 0.0768791
eAspectTrendratio 1.20515
eSlantMean -0.050738
eSlantStd 0.148646
eSlantStdnorm -2.92968
eSlantMedian -0.0602832
eSlantQuartdelta 0.185465
eSlantQuartdeltanorm -3.07657
eSlantKurt 3.25129
eSlantTrenddiff 0.086528
eRtopMean 0.726515
eRtopStd 0.120355
eRtopStdnorm 0.165661
eRtopMedian 0.744225
eRtopQuartdelta 0.18228
eRtopQuartdeltanorm 0.244926
eRtopKurt 3.52379
eRtopTrenddiff 0.0153076
eRbotMean 0.919628
eRbotStd 0.392044
eRbotStdnorm 0.426308
eRbotMedian 0.861715
eRbotQuartdelta 0.362682
eRbotQuartdeltanorm 0.420884
eRbotKurt 12.779
eRbotTrenddiff -0.210076
eRrightMean 0.81963
eRrightStd 0.0898052
eRrightStdnorm 0.109568
eRrightMedian 0.829901
eRrightQuartdelta 0.116549
eRrightQuartdeltanorm 0.140437
eRrightKurt 4.47307
eRrightTrenddiff -0.03887
eRleftMean 0.450588
eRleftStd 0.0939741
eRleftStdnorm 0.208559
eRleftMedian 0.437299
eRleftQuartdelta 0.12581
eRleftQuartdeltanorm 0.287699
eRleftKurt 3.57319
eRleftTrenddiff -0.0535695
lDurationMean 0.55028
lDurationStd 0.151029
lDurationStdnorm 0.274459
lDurationMedian 0.530023
lDurationQuartdelta 0.0562524
lDurationQuartdeltanorm 0.106132
lDurationKurt 21.5923
lDurationTrenddiff -0.0300013
lDurationTrendratio 0.945455
lWidthMean 13.4342
lWidthStd 2.10318
lWidthStdnorm 0.156554
lWidthMedian 13.4482
lWidthQuartdelta 2.2815
lWidthQuartdeltanorm 0.169651
lWidthKurt 3.52814
lWidthTrenddiff -1.3039
lWidthTrendratio 0.909395
lHeightMean 38.8407
lHeightStd 3.18341
lHeightStdnorm 0.0819606
lHeightMedian 38.025
lHeightQuartdelta 5.0895
lHeightQuartdeltanorm 0.133846
lHeightKurt 2.17095
lHeightTrenddiff -4.446
lHeightTrendratio 0.892045
lAspectMean 0.345748
lAspectStd 0.0451104
lAspectStdnorm 0.130472
lAspectMedian 0.349432
lAspectQuartdelta 0.0402843
lAspectQuartdeltanorm 0.115285
lAspectKurt 4.1561
lAspectTrenddiff -0.0161118
lAspectTrendratio 0.95478
lSlantMean 0.114241
lSlantStd 0.056691
lSlantStdnorm 0.496239
lSlantMedian 0.125976
lSlantQuartdelta 0.0660507
lSlantQuartdeltanorm 0.524314
lSlantKurt 6.55905
lSlantTrenddiff -0.0151411
lRtopMean 0.85273
lRtopStd 0.0626719
lRtopStdnorm 0.0734956
lRtopMedian 0.858224
lRtopQuartdelta 0.0726624
lRtopQuartdeltanorm 0.0846659
lRtopKurt 5.58709
lRtopTrenddiff 0.0128223
lRbotMean 0.536459
lRbotStd 0.1343
lRbotStdnorm 0.250346
lRbotMedian 0.506683
lRbotQuartdelta 0.141018
lRbotQuartdeltanorm 0.278316
lRbotKurt 9.34949
lRbotTrenddiff 0.0497395
lRrightMean 0.900094
lRrightStd 0.0583505
lRrightStdnorm 0.0648271
lRrightMedian 0.909779
lRrightQuartdelta 0.0445734
lRrightQuartdeltanorm 0.0489936
lRrightKurt 17.5584
lRrightTrenddiff -0.0118289
lRleftMean 0.28107
lRleftStd 0.0729304
lRleftStdnorm 0.259474
lRleftMedian 0.26089
lRleftQuartdelta 0.0612365
lRleftQuartdeltanorm 0.234721
lRleftKurt 7.20973
lRleftTrenddiff 0.0274731

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.99691
sumTouchScores 32.898
meanMovementTime 0.557031
numTouches 33
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.937641
sumTouchScores 18.7528
meanMovementTime 1.03763
numTouches 20
undershootPercentage 5
overshootPercentage 0

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 14.728
timePerZigzagCoV 0.127769
timePerZigzagSlope -0.0605649
meanError 2.41232
tremorFreq 6.05469
tremorRelPower 23.0931
tremorGyroAmpMean 0.0283738
tremorGyroAmpSlope -0.000718373
tremorGyroAmpCoV 0.31417
tremorCoordAmpMean 0.0986768
tremorCoordAmpSlope -0.000292674
tremorCoordAmpCoV 1.10157
tremorAccAmpMean 0.0634211
tremorAccAmpSlope -0.00428679
tremorAccAmpCoV 0.28831
tremorPcRelVar 0.808871
tremorPcX -0.150434
tremorPcY 0.98862

ZigZag Segment 1

Duration 18.0 s, Accuracy Estimate 2.29 (lower is better)

ZigZag Segment 2

Duration 14.0 s, Accuracy Estimate 2.424 (lower is better)

ZigZag Segment 3

Duration 14.48 s, Accuracy Estimate 2.441 (lower is better)

ZigZag Segment 4

Duration 13.24 s, Accuracy Estimate 2.621 (lower is better)

ZigZag Segment 5

Duration 13.92 s, Accuracy Estimate 2.285 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 11.784
timePerZigzagCoV 0.188652
timePerZigzagSlope -0.114392
zigzagHeightMean 86.3232
zigzagHeightCoV 0.0868398
zigzagHeightSlope 0.0406865
meanError 0.0467863
tremorFreq 6.05469
tremorRelPower 26.7836
tremorGyroAmpMean 0.043012
tremorGyroAmpSlope 0.00143481
tremorGyroAmpCoV 0.366242
tremorCoordAmpMean 0.165099
tremorCoordAmpSlope 0.0127219
tremorCoordAmpCoV 0.489817
tremorAccAmpMean 0.10013
tremorAccAmpSlope 0.00809128
tremorAccAmpCoV 0.34881
tremorPcRelVar 0.768132
tremorPcX 0.422761
tremorPcY -0.906241

ZigZag Offset Segment 1

Duration 14.4 s, Accuracy Estimate 0.057 (lower is better)

ZigZag Offset Segment 2

Duration 13.72 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 3

Duration 10.8 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 4

Duration 10.96 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 5

Duration 9.04 s, Accuracy Estimate 0.062 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.82}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.74}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.41661995465842083}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.3265470752974473}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5162799437415166}